Cyanolab is located at the interface of bioinformatics, experimental RNA biology and microbial systems biology. We have a long-standing interest in cyanobacteria and other photosynthetic organisms and their functions in the environment and their biotechnology. Current research activities are centered around the analysis of transcriptomic and epigenomic datasets to characterize regulatory RNAs and epigenetic modifications (see, for instance, our publications Hess et al., 2014; Georg et al., 2014; Klähn et al., 2015; Kopf et al., 2014; Kopf and Hess, 2015; Lott et al., 2015; Mitschke et al., 2011; Pfreundt et al., 2015; Voigt et al., 2014; Walworth et al., 2015).
On the basis of comparative genomic information, computational and experimental tools have been developed and applied to systematically identify novel regulatory RNAs (antisense and non-coding RNAs) in diverse pro- and eukaryotic organisms (Georg et al., 2009; Voß et al., 2009; Wright et al., 2013, 2014). We study CRISPR systems with the aim to understand their functions in antiviral defense and also beyond defense (see, for instance, the publications Hein et al., 2013; Scholz et al., 2013).
Particular research has been applied on marine microoganisms and the marine microbiome (Voss et al., 2013; Kopf et al., 2015). In the characterization of the marine microbiome we have contributed to the VAHINE project by studying the microbial metatranscriptome and community omposition in the South-West Pacific (Pfreundt et al., 2016a,b; Spungin et al., 2016; van Wambeke, 2016).